中枢神经系统表观遗传学药物展望
发表于《自然评论:药物发现》(Nature reviews. Drug discovery)2015年6月的一篇文章，在中枢神经系统(CNS)控制基因表达的表观遗传机制进行了综述，介绍了神经精神障碍的机制，基于上述内容文章重点提出新的治疗方法，逆转表观遗传因素的神经治疗条件。文章还对表观遗传因素的复杂性，和目前表观遗传因素在中枢神经系统疾病介入治疗的水平进行了讨论，并介绍了中枢神经系统(CNS)靶向表观遗传因素的药理学和临床前试验。最后，对基于表观遗传的治疗方法的改进策略和发展前景，以及组合药物和方法都进
发表于《自然评论:药物发现》(Nature reviews. Drug discovery)2015年6月的一篇文章，在中枢神经系统(CNS)控制基因表达的表观遗传机制进行了综述，介绍了神经精神障碍的机制，基于上述内容文章重点提出新的治疗方法，逆转表观遗传因素的神经治疗条件。文章还对表观遗传因素的复杂性，和目前表观遗传因素在中枢神经系统疾病介入治疗的水平进行了讨论，并介绍了中枢神经系统(CNS)靶向表观遗传因素的药理学和临床前试验。最后，对基于表观遗传的治疗方法的改进策略和发展前景，以及组合药物和方法都进行了阐述。
原文摘要：
Prospects for the development of epigenetic drugs for CNS conditions.
Advances in our understanding of the epigenetic mechanisms that control gene expression in the central nervous system (CNS) and their role in neuropsychiatric disorders are paving the way for a potential new therapeutic approach that is focused on reversing the epigenetic underpinnings of neuropsychiatric conditions. In this article, the complexity of epigenetic processes and the current level of proof for their involvement in CNS disorders are discussed. The preclinical evidence for efficacy of pharmacological approaches that target epigenetics in the CNS and the particular challenges of this approach are also examined. Finally, strategies to address these challenges through the development of improved evidence-based epigenetic therapeutics and through combining pharmacological and behavioural approaches are presented.
相关文章
评论
我要跟帖
.jpg)
